Condition: Hepatitis B · Sponsor: Guangzhou 8th People's Hospital
The main objective of this study is to compare the mother-to-infant transmission rates of hepatitis B between pregnant women receiving treatment with tenofovir alafenamide and those receiving treatment with tenofovir disoproxil fumarate, after administering the hepatitis B vaccine and hepatitis B immunoglobulin to their infants at birth. Investigators define the mother-to-infant transmission rate of hepatitis B as the proportion of infants who are HBsAg positive and have serum HBV DNA \>20 IU/mL at 28 weeks of age among all live births in the experimental group. Additionally, this study will also compare the incidence of congenital defects/malformations in infants born to mothers treated with tenofovir alafenamide and tenofovir disoproxil fumarate during the perinatal period to assess drug safety.
This description comes directly from the study's public registry record.
Calvin.Q Pan · +86 13632293277 · Panc01@nyu.edu
Always discuss trial participation with your own doctor first.
| Guangzhou Eighth People's Hospital, Guangzhou Medical University | Guangzhou, Guangdong, China | Recruiting |
| Guangzhou Women and Children's Medical Center | Guangzhou, Guangdong, China | Not Yet Recruiting |
| The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou | Guangzhou, Guangdong, China | Not Yet Recruiting |
| The Third Affiliated Hospital of Guangzhou Medical University | Guangzhou, Guangdong, China | Not Yet Recruiting |
| Shenzhen Baoan Women's and Children's Hospital | Shenzhen, Guangdong, China | Not Yet Recruiting |
| Shijiazhuang Maternity & Child Healthcare Hospital | Shijiazhuang, Hebei, China | Not Yet Recruiting |
| The Fifth Hospital of Shijiazhuang | Shijiazhuang, Hebei, China | Not Yet Recruiting |
| Xiangya Hospital, Central South University | Changsha, Hunan, China | Not Yet Recruiting |
| The First Affiliated Hospital of Wenzhou Medical University | Wenzhou, Zhejiang, China | Not Yet Recruiting |
| Beijing You 'an Hospital, Capital Medical University | Beijing, China | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06947356