← Eichor
Study identifier: NCT06946368 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Effectiveness of Exparel Anesthetic Administered by the Surgeon During Knee Surgery

Condition: Total Knee Arthroplasty  ·  Sponsor: The Cleveland Clinic

PhaseNA
Planned participants60
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersNo

About this study

Intra-articular Posteromedial Surgeon Administered (IPSA) Block in this study describes a new type of medical procedure where a surgeon provides anesthetic medication directly into a specific area inside a knee joint to numb the pain during knee surgery. Intra-articular refers to inside of knee joint, posteromedial refers to the back and inner side of a knee joint, and surgeon administered means a surgeon is performing the procedure. Patients You will be randomly assigned to one of these three treatment groups: Group 1: Patients in this group will receive IPSA block and Local Infiltration Analgesia (LIA). IPSA block is a pain numbing medication given by surgeon and injected inside the back and inner side of the knee joint. Local Infiltration Analgesia is a pain numbing medication injection given by the surgeon around the surgical knee area. The medications used in the procedure will be EXPAREL, and Bupivacaine HCL. Group 2 (Control): Patients in this group will receive Adductor Canal Block (ACB) and Local Infiltration Analgesia (LIA). ACB is a pain numbing injection given by anesthesiologist near the adductor canal, a passage in the mid-thigh that contains nerves connecting the knee region. Local Infiltration Analgesia is a pain numbing medication injection given by the surgeon around the surgical knee area. The medications used in the procedure will be EXPAREL, and Bupivacaine HCL. Group 3: Patients in this group will receive Local Infiltration Analgesia (LIA). Local…

This description comes directly from the study's public registry record.

Talk to the study team

Sanalkumar Krishnan, PhD  ·  216-445-7194  ·  krishns11@ccf.org

Jaime Shuster, PhD  ·  216- 906-0508  ·  shustej3@ccf.org

Always discuss trial participation with your own doctor first.

Locations (1)

Cleveland Clinic Lutheran HospitalCleveland, Ohio, United StatesRecruiting

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →

This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.

Source record: clinicaltrials.gov/study/NCT06946368