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Study identifier: NCT06943872 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)

Condition: Chronic Lymphocytic Leukemia · Small Lymphocytic Lymphoma  ·  Sponsor: BeOne Medicines

PhasePhase 3
Planned participants630
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this study is to compare how well sonrotoclax plus obinutuzumab works versus venetoclax plus rituximab in treating adults with relapsed and/or refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The study will also compare how well sonrotoclax plus rituximab works versus venetoclax plus rituxumab in treating adults with R/R CLL/SLL. The safety of these treatments will also be assessed.

This description comes directly from the study's public registry record.

Talk to the study team

Study Director  ·  1-877-828-5568  ·  clinicaltrials@beonemed.com

Always discuss trial participation with your own doctor first.

Locations (187)

Uci Health Laguna HillsLaguna Hills, California, United StatesRecruiting
Chao Family Comprehensive Cancer CenterOrange, California, United StatesRecruiting
Stanford Cancer InstitutePalo Alto, California, United StatesRecruiting
Scripps Prebys Cancer CenterSan Diego, California, United StatesRecruiting
Rocky Mountain Cancer Centers (Williams) UsorAurora, Colorado, United StatesRecruiting
Yale University Yale Cancer CenterNew Haven, Connecticut, United StatesRecruiting
Eastern Connecticut Hematology and OncologyNorwich, Connecticut, United StatesRecruiting
Cleveland Clinic FloridaWeston, Florida, United StatesRecruiting
Northwestern UniversityChicago, Illinois, United StatesRecruiting
Illinois Cancer Specialists (Niles) UsorNiles, Illinois, United StatesRecruiting
University of Louisville, Brown Cancer CenterLouisville, Kentucky, United StatesRecruiting
Mary Bird Perkins Cancer CenterBaton Rouge, Louisiana, United StatesRecruiting

+ 175 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06943872