Condition: Sickle Cell Disease (SCD) · Sponsor: University of Rochester
The WeDecide study is a large observational study comparing the long-term effects of matched related donor hematopoietic stem cell transplantation (MRD HCT) and non-transplant disease-modifying therapies (NT-DMT) for pediatric patients with sickle cell disease (SCD). The study aims to assess health-related quality of life (HRQoL), cognitive function, risks, and benefits of both treatments, including survival rates, chronic complications, and organ damage prevention. With 160 children in the MRD HCT group and 320 in the NT-DMT group, aged 3-20.9 years, the study will follow participants for three years, examining factors like disease severity, treatment history, and social determinants of health. By providing a comprehensive comparison, the study seeks to inform clinical decisions and improve understanding of SCD treatment outcomes, ultimately supporting families and healthcare providers in choosing the best treatment options.
This description comes directly from the study's public registry record.
John Horan, MD, MPH · 5852742345 · John_Horan@URMC.Rochester.edu
Savannah Pangrazio, BS · 5852750932 · Savannah_Pangrazio@URMC.Rochester.edu
Always discuss trial participation with your own doctor first.
| Children's of Alabama (MRD-HCT) | Birmingham, Alabama, United States | Recruiting |
| Children's of Alabama (NT-DMT) | Birmingham, Alabama, United States | Not Yet Recruiting |
| Nemours Children's Hospital, Delaware (MRD-HCT) | Wilmington, Delaware, United States | Recruiting |
| Children's National Hospital (MRD-HCT) | Washington D.C., District of Columbia, United States | Recruiting |
| Children's Healthcare of Atlanta (MRD-HCT) | Atlanta, Georgia, United States | Recruiting |
| Comer Children's Hospital (MRD-HCT) | Chicago, Illinois, United States | Recruiting |
| Riley Children's Hospital (MRD-HCT) | Indianapolis, Indiana, United States | Recruiting |
| Riley's Children Hospital (NT-DMT) | Indianapolis, Indiana, United States | Not Yet Recruiting |
| Boston Children's Hospital (MRD-HCT) | Boston, Massachusetts, United States | Recruiting |
| Boston Children's Hospital (NT-DMT) | Boston, Massachusetts, United States | Not Yet Recruiting |
| Wahington Univ in St Louis (NT-DMT) | St Louis, Missouri, United States | Not Yet Recruiting |
| Washington University in St Louis (MRD-HCT) | St Louis, Missouri, United States | Not Yet Recruiting |
+ 25 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06941389