Condition: Cystic Fibrosis (CF) · Cystic Fibrosis Pulmonary Exacerbation · Sponsor: Alexander Horsley
The CF-Tracker study is a community surveillance study, designed to understand the causes of exacerbations in people with cystic fibrosis (CF) (pwCF). These are episodes when pwCF become more unwell, typically characterised by increased cough, sputum, and breathlessness, and requiring prolonged courses of oral or intravenous antibiotics. This observational study applies a two-tiered approach over 12 months. It will recruit 200 pwCF to Group A, and an additional 100 pwCF to Group B, which follows the same format but includes additional in-clinic sampling. Participants will provide longitudinal clinical data and biological samples. Group B will be offered at 5 specialist CF centres (Manchester, Cardiff, Newcastle, Leeds, Liverpool), will include additional sampling methods at clinic visits, and additional scheduled clinic visits at 1 month and 6 months. Group B participants will be offered an in-person visit if they become unwell, so that samples can be collected before they start antibiotics. In Group B, those attending the Manchester clinic will have the option of taking part in a 12 month home environmental and pollution monitoring, and sleep monitoring (both optional arms). A pilot study will test the practicalities of running the same protocol in a paediatric population. This will consist of up to 25 children with CF (5-15 years) attending a paediatric clinic in one of the four core centres. Up to 40 healthy volunteers will be recruited to provide samples on a single oc…
This description comes directly from the study's public registry record.
Alexander Horsley, MA MBChB MRCP PhD FERS · 01612915869 · Alexander.horsley@manchester.ac.uk
Cheuk Ning Sharon Chau · 01613060797 · cheukningsharon.chau@manchester.ac.uk
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| Manchester Adult Cystic Fibrosis Centre | Manchester, Manchester, United Kingdom | Recruiting |
| Birmingham Heartlands Hospital | Birmingham, United Kingdom | Not Yet Recruiting |
| Blackpool Teaching Hospitals | Blackpool, United Kingdom | Not Yet Recruiting |
| Medical Research Unit, Bristol Royal Infirmary | Bristol, United Kingdom | Not Yet Recruiting |
| Cardiff and Vale University Health Board | Cardiff, United Kingdom | Recruiting |
| Royal Devon and Exeter Hospital (Wonford) | Exeter, United Kingdom | Recruiting |
| NHS Greater Glasgow and Clyde | Glasgow, United Kingdom | Recruiting |
| Leeds Adult CF Centre | Leeds, United Kingdom | Recruiting |
| Liverpool Heart & Chest Hospital | Liverpool, United Kingdom | Recruiting |
| Chest Unit Reception, King's College Hospital | London, United Kingdom | Not Yet Recruiting |
| Royal Brompton Hospital, Department of Cystic Fibrosis (Adult) | London, United Kingdom | Not Yet Recruiting |
| Newcastle Adult CF Centre | Newcastle upon Tyne, United Kingdom | Not Yet Recruiting |
+ 6 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06940531