Condition: Alcohol Use Disorder · Alcohol Abuse/Dependence · Alcohol Dependence · Sponsor: Anders Fink-Jensen, MD, DMSci
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), approved for the treatment of type 2 diabetes and obesity, have shown promise as a novel treatment for alcohol use disorder (AUD). This study aims to investigate whether the Glucose-dependent Insulinotropic Polypeptide/GLP-1RA tirzepatide will reduce alcohol consumption in patients with a dual diagnosis of AUD and schizophrenia, a population in dire need of improved treatment options. To further investigate the neurobiological underpinnings of a potential dampening effect on alcohol consumption, functional magnetic resonance imaging (fMRI) brain scans will be applied. The key anticipated outcomes include: * decreased alcohol consumption and * reduced alcohol cue-induced brain activity in the GIP/GLP-1-treated patient group compared with the placebo group. To the best of the investigators knowledge, this has never been examined before.
This description comes directly from the study's public registry record.
Søren B Jensen, MD · +45 60294963 · soeren.broegger.jensen@regionh.dk
Anders Fink-Jensen, MD, DMSc · +45 22755843 · anders.fink-jensen@regionh.dk
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| Department of Psychiatry, Aalborg University Hospital | Aalborg, Denmark, Denmark | Recruiting |
| Psychiatric Center Copenhagen, Frederiksberg Hospital | Frederiksberg, Denmark, Denmark | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06939088