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Study identifier: NCT06938724 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Omission of Local Therapies in Women Patients With HER2-positive or Triple-negative Breast Cancer

Condition: Breast Neoplasm Malignant Female  ·  Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

PhasePhase 2
Planned participants152
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

HER2-positive and Triple-negative are subtypes of breast cancer more sensitive to systemic therapies, where the complete pathological response rate may be higher than 50%. This gave rise to doubts about the usefulness of traditional local treatments for such responders. Omission of surgery after vacuum assisted breast biopsy (VABB) as well omission of radiotherapy after conservative surgery would now seem to be reasonable alternatives to standard care for highly selected patients, in whom systemic treatments have provided the maximum response.

This description comes directly from the study's public registry record.

Talk to the study team

Massimiliano Gennaro, MD  ·  +390223903246  ·  massimiliano.gennaro@istitutotumori.mi.it

Kiara Muca  ·  +390223903908  ·  kiara.muca@istitutotumori.mi.it

Always discuss trial participation with your own doctor first.

Locations (1)

Fondazione IRCCS Istituto Nazionale Tumori MilanoMilan, ItalyRecruiting

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Source record: clinicaltrials.gov/study/NCT06938724