Condition: Cervical Dystonia · Sponsor: Ipsen
The purpose of this study is to evaluate the efficacy and safety of the study drug, Corabotase (also known as IPN10200), and to assess how well it works when compared with placebo in treating Cervical Dystonia (CD) in adults. CD can cause a series of abnormalities and symptoms in the head and neck that can lead to neck pain and stiffness, and headaches. CD is believed to involve deep parts within the brain that control movement, but genetic factors, environmental factors, and abnormalities in the brain may also play a role. The usual treatment for CD includes injecting BoNT into the affected muscles, but the treatment only lasts about 3 months. Corabotase is designed to last for a longer period. The study will consist of two periods: 1. A Screening Period of up to 4 weeks (28 days) to assess whether a participant can take part in the study and requires at least one visit. 2. A Treatment Period of 36 weeks. On Day 1 of the treatment period, participants will receive either Corabotase Dose A or Dose B (additional participants may receive Corabotase Dose C) of the study drug, or placebo distributed into different muscles in the head, neck and shoulders. Participants may continue some other medications, but details need to be recorded. There will be 10 visits to the clinic in person and one remote visits (phone call) (12 visits to the clinic for participants who receive Dose C). Participants will undergo blood samplings, urine collections, physical/neurological examinations…
This description comes directly from the study's public registry record.
Ipsen Clinical Study Enquiries · See e mail · clinical.trials@ipsen.com
Always discuss trial participation with your own doctor first.
| University of Arizona Health Sciences - Neurology | Tucson, Arizona, United States | Active Not Recruiting |
| Parkinson's & Mvmt Disorders Inst | Fountain Valley, California, United States | Recruiting |
| Parkinson's Ds & Mvt Disorders Cntr | Boca Raton, Florida, United States | Recruiting |
| USF Health Byrd Alzheimer's Institute | Tampa, Florida, United States | Not Yet Recruiting |
| Emory Brain Health Center | Atlanta, Georgia, United States | Recruiting |
| Rush Medical Center | Chicago, Illinois, United States | Active Not Recruiting |
| Quest Research Institute | Farmington Hills, Michigan, United States | Recruiting |
| Ichan Sch of Medicine @ Mt. Sinai | New York, New York, United States | Recruiting |
| Kingfisher Cooperative | Spokane, Washington, United States | Recruiting |
| Fakultni nemocnice u sv. Anny v Brne - I. Neurologicka klinika | Brno, Czechia | Recruiting |
| MINKSneuro s.r.o. | Brno, Czechia | Active Not Recruiting |
| NEUROHK s.r.o. | Choceň, Czechia | Recruiting |
+ 32 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06937931