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Study identifier: NCT06937229 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)

Condition: Alzheimer Disease · Agitation  ·  Sponsor: Bristol-Myers Squibb

PhasePhase 3
Planned participants650
Who can joinAll sexes, 55 Years to 90 Years
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the long-term efficacy and safety of combined formulation of xanomeline tartrate/trospium chloride in an immediate release (IR) capsule (KarXT) and xanomeline enteric capsules (KarX-EC) in participants with agitation associated with Alzheimer's Disease who completed the parent studies CN012-0023 or CN012-0024.

This description comes directly from the study's public registry record.

Talk to the study team

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com, www.BMSStudyConnect.com  ·  855-907-3286  ·  Clinical.Trials@bms.com

First line of the email MUST contain NCT # and Site #.

Always discuss trial participation with your own doctor first.

Locations (258)

Local Institution - 2609Chandler, Arizona, United StatesNot Yet Recruiting
Imaging EndpointsScottsdale, Arizona, United StatesRecruiting
Local Institution - 1657Anaheim, California, United StatesNot Yet Recruiting
Local Institution - 2620Canoga Park, California, United StatesNot Yet Recruiting
Local Institution - 1637La Jolla, California, United StatesNot Yet Recruiting
Local Institution - 2625Long Beach, California, United StatesNot Yet Recruiting
Local Institution - 2607Long Beach, California, United StatesNot Yet Recruiting
Local Institution - 2642Long Beach, California, United StatesNot Yet Recruiting
Local Institution - 2649Orange, California, United StatesNot Yet Recruiting
Local Institution - 2613Pasadena, California, United StatesNot Yet Recruiting
Local Institution - 1662Pomona, California, United StatesNot Yet Recruiting
Local Institution - 1639Torrance, California, United StatesNot Yet Recruiting

+ 246 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06937229