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Study identifier: NCT06937203 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A First-In-Human Study of ARO-ALK7 in Adults With Obesity With and Without Type 2 Diabetes Mellitus

Condition: Obesity · Diabetes Mellitus, Type 2  ·  Sponsor: Arrowhead Pharmaceuticals

PhasePhase 1/Phase 2
Planned participants150
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

This is a Phase 1/2a double-blind dose-escalating study to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple doses of ARO-ALK7 in adult participants with obesity without Type 2 Diabetes Mellitus (T2DM) (Part 1), and the safety, tolerability, and PD of multiple doses of ARO-ALK7 in adult participants with obesity with and without T2DM, either as monotherapy or in combination with tirzepatide (Part 2).

This description comes directly from the study's public registry record.

Talk to the study team

Medical Monitor  ·  626-304-3400  ·  AROALK71001@arrowheadpharma.com

Always discuss trial participation with your own doctor first.

Locations (8)

Research Site 8Morayfield, QLC, AustraliaRecruiting
Research Site 7Nedlands, Western Australia, AustraliaNot Yet Recruiting
Research Site 5Grafton, Auckland, New ZealandRecruiting
Research Site 6Papatoetoe, Auckland, New ZealandRecruiting
Research Site 3Takapuna, Auckland, New ZealandRecruiting
Research Site 1Auckland, New ZealandRecruiting
Research Site 2Christchurch, New ZealandRecruiting
Research Site 4Rotorua, New ZealandRecruiting

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Source record: clinicaltrials.gov/study/NCT06937203