Condition: Diabetes Mellitus Type 2 · Sponsor: Seattle Children's Hospital
High-resistance, short-duration inspiratory muscle strength training (IMST) is a novel lifestyle intervention involving 30 inhalations against a resistive load which requires only \~5 min/day and is thus ideal for youth with T2D (Y-T2D). Investigators seek to 1: assess changes in casual and 24-hr SBP, endothelial function, and arterial stiffness after 3 months of IMST vs. sham training in Y-T2D, 2: Define changes in eGFR andalbuminuria after 3 months of IMST vs. sham in Y-T2D, 3: Interrogate mechanisms of IMST by translational assessments of NO bioavailability, endothelial NO synthase (eNOS) activation, and ROS/oxidative stress, and determine the role of circulating factors.
This description comes directly from the study's public registry record.
Kalie Tommerdahl, MD · (206) 616-9015 · ktomme@uw.edu
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| Seattle Children's Hospital | Seattle, Washington, United States | Recruiting |
| University of Washington Medicine Diabetes Institute | Seattle, Washington, United States | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06936670