Condition: Coronary Heart Disease (CHD) · Sponsor: Shanghai Zhongshan Hospital
Intensive lipid-lowering therapy is a cornerstone treatment for coronary heart disease (CHD). However, coronary plaque progression persists in a subset of patients even under intensive lipid-lowering therapy, which may be associated with residual lipid and inflammatory risks. Current research in this area remains largely confined to post hoc analyses of randomized controlled trials , with a notable scarcity of prospective follow-up cohorts. The investigators propose that establishing a prospective cohort will provide more authentic insights into the associations between residual risk factors and plaque progression. In this project, the investigators aim to establish a well-characterized CHD cohort with comprehensive data collection, good compliance, and an appropriate sample size. By focusing on non-target lesions within the target vessel and utilizing intravascular ultrasound (IVUS), the investigators will investigate the impact of residual lipid and inflammatory risks on plaque progression during intensive lipid-lowering therapy.
This description comes directly from the study's public registry record.
Chunfeng Dai, M.D. · 86-021-64041990 · dai.chunfeng@zs-hospital.sh.cn
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| Shanghai Zhongshan Hospital | Shanghai, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06936111