Condition: Immunoglobulin A Nephropathy (IgAN) · Sponsor: Biogen
In this study, researchers will learn more about the use of felzartamab in participants with immunoglobulin A nephropathy (IgAN). IgAN is a kidney disease caused by the buildup of an antibody called IgA in the kidneys over time. In people with IgAN, abnormal IgA and other antibodies form clusters that build up in the small filters of the kidneys, which leads to inflammation and damage. Felzartamab is designed to target certain immune cells that produce these abnormal antibodies. This study will focus on participants who have protein in their urine (proteinuria) as a result of damaged kidneys. The main goal of the study is to learn about the effect felzartamab has on proteinuria. The main question that researchers want to answer is: • How much does the amount of protein in the urine change from the start of the study to Week 36? Researchers will learn about the effect felzartamab has on the kidneys' ability to filter blood. They will also learn more about the safety of felzartamab and how it is processed by the body. The study will be done as follows: * Participants will be screened to check if they can join the study. * Participants will be randomized to receive either felzartamab or a placebo. A placebo looks like the study drug but contains no real medicine. * Neither the researchers nor the participants will know what the participants will receive. * Participants will receive felzartamab or placebo as intravenous (IV) infusions. The treatment period will last 24 weeks…
This description comes directly from the study's public registry record.
US Biogen Clinical Trial Center · 866-633-4636 · clinicaltrials@biogen.com
Global Biogen Clinical Trial Center · clinicaltrials@biogen.com
Always discuss trial participation with your own doctor first.
| Applied Research Center of Arkansas | Little Rock, Arkansas, United States | Recruiting |
| Kidney & Hypertension Center - Apple Valley | Apple Valley, California, United States | Recruiting |
| Scripps Green Hospital | Carlsbad, California, United States | Recruiting |
| National Institute of clinical Research Administration Office | Garden Grove, California, United States | Withdrawn |
| UCLA Health David Geffen School of Medicine | Los Angeles, California, United States | Recruiting |
| FOMAT Medical Research - FOMAT - PPDS | Oxnard, California, United States | Recruiting |
| North America Research Institute-San Dimas | San Dimas, California, United States | Recruiting |
| Nova Clinical Research, LLC | Bradenton, Florida, United States | Recruiting |
| University of Florida - Gainesville - 1600 SW Archer Rd | Gainesville, Florida, United States | Not Yet Recruiting |
| Royal Research, Corp. | Hollywood, Florida, United States | Recruiting |
| Central Florida Kidney Specialists | Orlando, Florida, United States | Recruiting |
| CDC Research Institute, LLC | Port Saint Lucie, Florida, United States | Recruiting |
+ 239 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06935357