Condition: Eldery People · Cognitive Decline · Memory Decline · Sponsor: University of Cincinnati
The purpose of this placebo-controlled trial is to compare the effects of 24-weeks supplementation with LPC-DHA and TAG-DHA on cerebrospinal fluid and blood DHA levels, as well as biomarkers of central neurodegenerative and neurotrophic activity, in elderly adults experiencing early signs of cognitive/memory decline including those with mild cognitive impairment (MCI). Extant evidence supports our overarching hypothesis that LPC-DHA supplementation will be more effective than TAG-DHA for increasing central (CSF) DHA levels and improving biomarker profiles in elderly adults. To assess this hypothesis, the following aims are proposed: SPECIFIC AIM 1: To compare the effects of LPC-DHA and TAG-DHA supplementation on peripheral and CSF DHA levels in elderly adults experiencing early signs of cognitive/memory decline. SPECIFIC AIM 2: To compare the effects of LPC-DHA and TAG-DHA supplementation on neurotrophic and neurodegenerative biomarkers. Secondary Aim: To investigate whether changes in CSF DHA levels correlate with changes in objective measures of executive functioning and episodic memory performance.
This description comes directly from the study's public registry record.
Robert McNamara, PhD · 513-558-6831 · mcnamar@ucmail.uc.edu
Robert Krikorian, PhD · 513-558-6831 · KRIKORR@UCMAIL.UC.EDU
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| University of Cincinnati, Department of Psychiatry and Behavioral Neuroscience | Cincinnati, Ohio, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06933095