Condition: Peritoneal Carcinomatosis · Peritoneal Metastases From Colorectal Cancer · Sponsor: Hospices Civils de Lyon
Colorectal cancer is highly prevalent in France, ranking second among women and third among men. Its primary metastatic sites include the liver, lungs, and peritoneum. For peritoneal metastases, when the disease is moderately extensive, cytoreductive surgery is recommended in an expert centre. Following this procedure, the surgeon uses the CC-Score (Completeness of Cytoreduction after Surgery Score) to assess the completeness of surgical resection by evaluating the largest remaining tumor residue. This subjective score is currently the main prognostic factor for oncological outcomes post-surgery. However, there is no objective score based on biological criteria to evaluate the radicality of resection, despite the hypothesis that the micrometastatic component of the disease could be biologically assessed using appropriate circulating markers. New biomarkers are emerging and appear relevant for determining the presence of tumor residual disease. Notable among these are circulating tumor DNA, which can detect mutated DNA released by tumor cells into the patient's blood through high-throughput sequencing, and new markers related to epigenetic modifications in cancer cells. These markers target specific nucleosomes or the transcription factor CTCF and show promise in detecting residual disease. To effectively use these markers for constructing a biological score to detect residual disease in peritoneal carcinomatosis, it is essential to understand their perioperative kinetics. T…
This description comes directly from the study's public registry record.
Vahan KEPENEKIAN, MD, PhD · +33 478 862 371 · vahan.kepenekian@chu-lyon.fr
Laurent VILLENEUVE, PhD · +33478 864 536 · laurent.villeneuve@chu-lyon.fr
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| Hôpital Lyon Sud | Pierre-Bénite, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06929013