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Study identifier: NCT06927375 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study on the Combined Use of Tocilizumab and Flupentixol-Melitracen in the Treatment of Thyroid-Associated Ophthalmopathy

Condition: Thyroid-Associated Ophthalmopathy  ·  Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

PhasePhase 4
Planned participants60
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

Thyroid-associated ophthalmopathy (TAO) is a serious, progressive, vision-threatening autoimmune disease that can be categorized into mild, moderate, and severe stages based on severity. The activity of TAO is commonly evaluated using the Clinical Activity Score (CAS). Tocilizumab serves as a second-line treatment option for patients with moderate to severe active TAO. Additionally, it is common for TAO patients to experience anxiety, which may exacerbate their condition and negatively impact prognosis. Therefore, we have designed this randomized controlled study to evaluate the impact of Flupentixol Melitracen (Lepan) on the treatment outcomes of participants receiving Tocilizumab (Actemra).

This description comes directly from the study's public registry record.

Talk to the study team

Yingli Lu  ·  (021)+86 13636352507  ·  luyingli2008@126.com

qin li  ·  (021) +86 13564691094

Always discuss trial participation with your own doctor first.

Locations (1)

Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of MedicineShanghai, Shanghai Municipality, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06927375