● Recruiting

A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)

Condition: Breast Neoplasms · Sponsor: Bristol-Myers Squibb

PhasePhase 2/Phase 3

Planned participants500

Who can joinAll sexes, 18 Years to no upper limit

Healthy volunteersNo

About this study

The purpose of this study is to assess the efficacy and safety of iza-bren, a bi-specific antibody-drug conjugate against EGFR and HER3 with a topoisomerase inhibitor payload versus treatment of physician's choice (TPC) (paclitaxel, nab-paclitaxel, carboplatin plus gemcitabine, and capecitabine) for the treatment of first-line metastatic triple-negative breast cancer (TNBC) or estrogen receptor (ER)-low, human epidermal growth factor receptor 2 (HER2)-negative BC patients who are not candidates for anti-PD(L)1 therapy and endocrine therapies.

This description comes directly from the study's public registry record.

Talk to the study team

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com · 855-907-3286 · Clinical.Trials@bms.com

First line of the email MUST contain NCT # and Site #.

Always discuss trial participation with your own doctor first.

Locations (295)

Local Institution - 0303	Hot Springs, Arkansas, United States	Not Yet Recruiting
Helios Clinical Research	Cerritos, California, United States	Recruiting
Local Institution - 0307	Cerritos, California, United States	Withdrawn
Local Institution - 0308	Cerritos, California, United States	Withdrawn
Local Institution - 0309	Cerritos, California, United States	Withdrawn
Local Institution - 0311	Long Beach, California, United States	Withdrawn
USC/Norris Comprehensive Cancer Center	Los Angeles, California, United States	Recruiting
Valkyrie Clinical Trials	Los Angeles, California, United States	Recruiting
USC Norris Oncology/Hematology-Newport Beach	Newport Beach, California, United States	Recruiting
Local Institution - 0358	Stanford, California, United States	Not Yet Recruiting
Local Institution - 0289	Aurora, Colorado, United States	Not Yet Recruiting
Rocky Mountain Cancer Centers	Denver, Colorado, United States	Recruiting

+ 283 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06926868