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Study identifier: NCT06926205 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

CHOP Plus Mosunetuzumab as First Line in Patients With Richter´s Syndrome: a Phase II Study of the Spanish Group of CLL

Condition: Richter Syndrome  ·  Sponsor: GELLC (Grupo Español de Leucemia Linfocítica Crónica)

PhasePhase 2
Planned participants34
Who can joinAll sexes, 18 Years to 79 Years
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn if drug Mosunetuzumab works to treat Richter´syndrome . It will also learn about the safety of drug Mosunetuzumab. The main questions it aims to evaluate the efficacy of mosunetuzumab combined with CHOP (M-CHOP) after the end of induction in patients with Richter´s Syndrome who have never received thearapy What medical problems do participants have when taking drug Mosunetuzumab? Patients with Richter´s Syndrome Participants will: Take drug Mosunetuzumab+CHOP during 6 cycle and they if they are not candidate to Alothasplant continuing 11 cycles more with mosunetuzumab on monoterapy Visit the clinic once every 23weeks for checkups and tests

This description comes directly from the study's public registry record.

Talk to the study team

Ana Méndez, Sponsor representative  ·  +34 942 203450  ·  administracion@gellc.es

Teresa Pascual Tome, CRO representative  ·  +34 91 456 11 05  ·  t.pascual@evidenze.com

Always discuss trial participation with your own doctor first.

Locations (16)

Hospital Vall HebronBarcelona, Barcelona, SpainRecruiting
Hospital Clínic y Porvincial de BarcelonaBarcelona, Barcelona, SpainRecruiting
ICO Hospitalet Duran i ReynalsL'Hospitalet de Llobregat, Barcelona, SpainRecruiting
H Marqués de ValdecillaSantander, Cantabria, SpainRecruiting
Complejo Hospitalario Universitario de Gran Canaria Dr. NegrínLas Palmas de Gran Canaria, Las Palmas de Gran Canaria, SpainActive Not Recruiting
Hospital Universitario La PrincesaMadrid, Madrid, SpainRecruiting
Hospital Universitario 12 de OctubreMadrid, Madrid, SpainRecruiting
Hospital General Universitario Morales MeseguerMurcia, Murcia, SpainActive Not Recruiting
Hospital Universitario Costa del SolMarbella, Málaga, SpainActive Not Recruiting
Hospital Universitario Central de AsturiasOviedo, Principality of Asturias, SpainRecruiting
Hospital Universitario de SalamancaSalamanca, Salamanca, SpainActive Not Recruiting
Hospital de DonostiaDonostia / San Sebastian, San Sebastian, SpainRecruiting

+ 4 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06926205