Condition: Invasive Mold Infections · Sponsor: Basilea Pharmaceutica
The purpose of this study is to evaluate the efficacy and safety of fosmanogepix (administered IV or oral) for the treatment of adult patients with invasive mold infections. The study is looking for patients who have been diagnosed with invasive mold infections. The maximum study duration will be approximately 8 months, including a target study treatment duration of 84 days which can be extended up to 180 days and follow-up period. The patient will be assigned to one of two treatment cohorts: Cohort A (primary therapy): Patients will receive either the study drug or institutional standard of care antifungal treatment. Cohort B (salvage treatment; i.e. treatment given after patients did not respond to previous treatments or did not tolerate them): Patients will receive the study drug The primary aim is to compare the all cause mortality with a fixed threshold at Day 42.
This description comes directly from the study's public registry record.
Alison Kuchta, MD · +41616061243 · kuchtaa@basileapharma.com
Marc Engelhardt, MD · +41797010551 · marc.engelhardt@basilea.com
Always discuss trial participation with your own doctor first.
| University of Alabama at Birmingham School of Medicine, Department of Medicine | Birmingham, Alabama, United States | Recruiting |
| City of Hope | Duarte, California, United States | Recruiting |
| David Geffen School of Medicine at UCLA | Los Angeles, California, United States | Recruiting |
| UC Davis Medical Center | Sacramento, California, United States | Recruiting |
| Memorial Healthcare System | Hollywood, Florida, United States | Recruiting |
| Rush University Medical Center, Division of Infectious Diseases | Chicago, Illinois, United States | Recruiting |
| University of Kentucky Medical Center, Division of Infectious Diseases | Lexington, Kentucky, United States | Recruiting |
| Johns Hopkins Hospital | Baltimore, Maryland, United States | Recruiting |
| University of Michigan Health System (UMHS) - A. Alfred Taubman Health Care Center | Ann Arbor, Michigan, United States | Recruiting |
| Karmanos Cancer Institute - Detroit | Detroit, Michigan, United States | Recruiting |
| University of Minnesota, M Health Fairview Medical Center | Minneapolis, Minnesota, United States | Recruiting |
| Washington University School of Medicine, Infectious Diseases Clinical Research Unit | St Louis, Missouri, United States | Recruiting |
+ 64 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06925321