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Study identifier: NCT06924086 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

The Children's Adaptive Deep Brain Stimulation for Epilepsy Trial

Condition: Lennox Gastaut Syndrome (LGS)  ·  Sponsor: University College, London

PhaseNA
Planned participants22
Who can joinAll sexes, 5 Years to 14 Years
Healthy volunteersNo

About this study

The CADET Trial will investigate the effectiveness of deep brain stimulation (DBS) to reduce the frequency of seizures in children with Lennox-Gastaut syndrome (LGS). The CADET Trial will use a non-CE/UKCA marked device - the Picostim DBS system. The SMART-DBS study is a sub-study of the CADET Trial. SMART-DBS will investigate the application of adaptive DBS for the treatment of children with LGS. Children will be recruited after they exit from either the prior 'CADET Pilot Study' or 'CADET Trial' - meaning that these children will already be receiving therapy with an already implanted Picostim device.

This description comes directly from the study's public registry record.

Talk to the study team

Rory J Piper, MRCS, PhD  ·  +44 20 7405 9200  ·  Rory.Piper@ucl.ac.uk

Always discuss trial participation with your own doctor first.

Locations (1)

Great Ormond Street Hospital NHS Foundation TrustLondon, United KingdomRecruiting

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Source record: clinicaltrials.gov/study/NCT06924086