Condition: Metastatic Colorectal Cancer (mCRC) · Sponsor: Isofol Medical AB
This is a clinical research study taking place in Germany. Patients with colorectal cancer at a stage of the disease where metastases occur may take part in the study. A maximum of 90 people will participate in the study. There is already a standard therapy for treatment of colorectal cancer. This therapy contains a combination of the medicines leucovorin, fluorouracil, oxaliplatin/irinotecan and bevacizumab/cetuximab/panitumumab. The sponsoring company is developing the new therapy called arfolitixorin. In this study, patients with colorectal cancer will be given arfolitixorin instead of the standard treatment leucovorin. Different patients will receive treatment with different strengths (doses) of arfolitixorin. Treatment with fluorouracil, oxaliplatin/irinotecan and bevacizumab/cetuximab/panitumumab will also be administrated. The researchers want to find out if arfolitixorin could have an advantage over the standard therapy with leucovorin. They also want to investigate which dose of arfolitixorin is the maximum tolerated dose and if arfolitixorin is safe to use. The product being tested, arfolitixorin, like leucovorin, belongs to a group of substances called folates which are naturally occurring forms of a type of B vitamin. Folates are administered in combination with one or more chemotherapeutic agents to enhance their effect on cancer cells. The main mechanism of action of arfolitixorin is the same as that of leucovorin when used together with fluorouracil. Howev…
This description comes directly from the study's public registry record.
Roger Tell, MD, PhD · +46760293911 · roger.tell@isofolmedical.com
Always discuss trial participation with your own doctor first.
| Charité - Universitaetsmedizin Berlin | Berlin, Germany | Recruiting |
| Universitaetsklinikum Essen AöR, Department of Medical Oncology | Essen, Germany | Not Yet Recruiting |
| Muenchen Klinik gGmbH, Klinik für Onkologie und Hämatologie | München, Germany | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06922383