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Study identifier: NCT06922318 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

The COSMYC Trial (COmbined Suppression of MYC)

Condition: Metastatic Castration-resistant Prostate Cancer  ·  Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

PhasePhase 2
Planned participants50
Who can joinMale, 18 Years to no upper limit
Healthy volunteersNo

About this study

This research is being done to determine if receiving the combination of testosterone and ZEN-3694 followed by the combination of enzalutamide plus ZEN-3694 will decrease the size of tumors in patients with prostate cancer that has become resistant to castration and other therapies. The investigators also want to determine if dosing first with the combination of testosterone and ZEN-3694 may cause enzalutamide and ZEN-3694 to work more effectively.

This description comes directly from the study's public registry record.

Talk to the study team

Samuel Denmeade, MD  ·  410-733-3232  ·  denmesa@jhmi.edu

Sin Chan, MS  ·  410-614-3630  ·  schan44@jhmi.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Johns Hopkins Sidney Kimmel Comprehensive Cancer CenterBaltimore, Maryland, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06922318