Condition: Pneumonia Childhood · Pneumonia · Lung Ultrasound · Sponsor: Meyer Children's Hospital IRCCS
Pneumonia is a major cause of illness and death in children, with an annual incidence of about 3.3 per 1,000 in those under five years old, many requiring hospitalization. The diagnosis is challenging due to the absence of a universally accepted gold standard, leading to variability in emergency settings. Current guidelines recommend diagnosis based on history and physical examination, which do not reliably differentiate pneumonia from other respiratory infections or identify whether it is bacterial or viral in nature. This uncertainty can lead to the unnecessary use of antibiotics. Commonly used chest X-rays have limitations such as low sensitivity, moderate interobserver reliability, and the inability to distinguish bacterial from viral pneumonia. In contrast, lung ultrasound has shown high sensitivity and specificity for diagnosing pneumonia in children. However, lung ultrasound also cannot reliably distinguish between bacterial and viral causes and might lead to increased antibiotic prescriptions by detecting minor lung consolidations not seen on chest X-rays. Despite these issues, lung ultrasound is widely used in pediatric pulmonary assessment. The primary objective of the study is to determine if using lung ultrasound for diagnosing pneumonia in children can reduce antibiotic prescriptions compared to the standard care approach-which mainly relies on clinical diagnosis (often supplemented by chest X-ray and blood tests in selected cases). The secondary objective is t…
This description comes directly from the study's public registry record.
Niccolò Parri, MD · +390555662320/2634 · niccolo.parri@meyer.it
Martina Cecchetti, MD · luscaptrial@gmail.com
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| Rady Childrens/UCSD | San Diego, California, United States | Active Not Recruiting |
| Yale New Haven Children's Hospital | New Haven, Connecticut, United States | Recruiting |
| Columbia University | New York, New York, United States | Not Yet Recruiting |
| University of Wisconsin | Madison, Wisconsin, United States | Active Not Recruiting |
| Schneider Children's Hospital | Petah Tikva, Israel | Not Yet Recruiting |
| Meyer Children's Hospital IRCCS | Florence, Italy, Italy | Recruiting |
| ASST Papa Giovanni XXIII | Bergamo, Italy | Recruiting |
| IRCCS Sant'Orsola | Bologna, Italy | Recruiting |
| Ospedale dei Bambini | Brescia, Italy | Not Yet Recruiting |
| IRCCS Istituto Giannina Gaslini | Genova, Italy | Recruiting |
| IRCCS Fondazione Cà Granda - Policlinico | Milan, Italy | Active Not Recruiting |
| Ospedale Pediatrico Santobono - Pausillipon | Naples, Italy | Not Yet Recruiting |
+ 6 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06921993