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Study identifier: NCT06918652 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Surgical vs Endoscopic Treatments as ImmunoModulating Interventions in High-Risk Acute Calculous Cholecystitis

Condition: High-risk Patients With Acute Calculous Cholecystitis (ACC)  ·  Sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia

PhaseNA
Planned participants80
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Randomized controlled trial on high-risk patients with ACC. Consecutive patients with a diagnosis of ACC, if they meet the inclusion and exclusion criteria, will be randomized to receive Laparoscopic cholecystectomy (LC) or transmural ultrasound-guided gallbladder drainage (TUGD) with lumen-apposing self-expandable metal stents (LAMSs) within 10 days from onset of symptoms. Blood cultures will be performed at the time of admission, just before the procedure, 24 ± 3h after procedure, 72 ± 3h after procedure. Bile samples will be taken during the procedure for microbiological exam and culture. Blood samples will collected from all patients at the time of admission, just before the procedure, 24 ± 3h after procedure, 72 ± 3h after procedure. The follow-up will be performed after 30 days and after 6 months from intervention with an outpatient medical examination.

This description comes directly from the study's public registry record.

Talk to the study team

Luca Ansaloni, MD  ·  +390382502530  ·  l.andaloni@smatteo.pv.it

Always discuss trial participation with your own doctor first.

Locations (1)

SC Chirurgia Generale 1 - Fondazione IRCCS Policlinico San MatteoPavia, Pavia, ItalyRecruiting

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Source record: clinicaltrials.gov/study/NCT06918652