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Study identifier: NCT06917079 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

Condition: Non-Small Cell Lung Cancer · NSCLC · PDAC - Pancreatic Ductal Adenocarcinoma  ·  Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

PhasePhase 1
Planned participants665
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

A first in human study to evaluate the safety and preliminary antitumor activity of BBO-11818, a pan-KRAS inhibitor, in subjects with locally advanced unresectable or metastatic KRAS mutant solid tumors.

This description comes directly from the study's public registry record.

Talk to the study team

TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)  ·  (650) 405-4770  ·  tbbo11818-101ct.gov@bbotx.com

Always discuss trial participation with your own doctor first.

Locations (17)

The Angeles Clinic and Research Institute - West Los Angeles OfficeLos Angeles, California, United StatesRecruiting
University of California DavisSacramento, California, United StatesRecruiting
University of California San Diego Moores Cancer CenterSan Diego, California, United StatesRecruiting
University of California San Francisco Helen Diller Family Comprehensive Cancer CenterSan Francisco, California, United StatesRecruiting
Yale UniversityNew Haven, Connecticut, United StatesRecruiting
Moffitt Cancer CenterTampa, Florida, United StatesRecruiting
OSF Healthcare Cancer InstitutePeoria, Illinois, United StatesRecruiting
Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
NYU Langone HealthNew York, New York, United StatesRecruiting
Columbia University Irving Medical CenterNew York, New York, United StatesRecruiting
Vanderbilt University Medical CenterNashville, Tennessee, United StatesRecruiting
Sarah Cannon Research Institute at Mary CrowleyDallas, Texas, United StatesRecruiting

+ 5 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06917079