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Study identifier: NCT06916806 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.

Condition: Systemic Lupus Erythematosus · Idiopathic Inflammatory Myopathies · Rheumatoid Arthritis  ·  Sponsor: AstraZeneca

PhasePhase 1
Planned participants72
Who can joinAll sexes, 18 Years to 70 Years
Healthy volunteersNo

About this study

The purpose of this study is to measure the safety, tolerability, PK, and PD of AZD5492 administered subcutaneously in adult participants with SLE or IIM or RA Study details include: • The study duration will be a minimum of 180 days in addition to the screening period. Additional follow-up visits may be required up to 12 months from study start. * Depending on the study part they are assigned to, participants will be administered AZD5492 once (Part 1) or twice (Part 2). * Study visits will occur at: Screening, Days 1-4, 8, 15, 22, 30, 60, 90, 120, 150, and 180 in Part 1, Screening, Days 1-4, 8-11, 15, 22, 29, 43, 60, 90, 120, 150, and 180 in Part 2.

This description comes directly from the study's public registry record.

Talk to the study team

AstraZeneca Clinical Study Information Center  ·  1-877-240-9479  ·  information.center@astrazeneca.com

Always discuss trial participation with your own doctor first.

Locations (37)

Research SiteAnniston, Alabama, United StatesRecruiting
Research SiteBirmingham, Alabama, United StatesWithdrawn
Research SiteLa Jolla, California, United StatesNot Yet Recruiting
Research SiteSacramento, California, United StatesNot Yet Recruiting
Research SiteIowa City, Iowa, United StatesRecruiting
Research SiteOmaha, Nebraska, United StatesNot Yet Recruiting
Research SiteChapel Hill, North Carolina, United StatesNot Yet Recruiting
Research SiteHamilton, Ontario, CanadaNot Yet Recruiting
Research SiteSherbrooke, Quebec, CanadaRecruiting
Research SiteBeijing, ChinaRecruiting
Research SiteShanghai, ChinaRecruiting
Research SiteWuhan, ChinaRecruiting

+ 25 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06916806