Condition: Relapsed CLL · Refractory CLL · Refractory Lymphoma · Sponsor: Paolo Caimi, MD
CAR-T cell treatment of refractory lymphoma has shown success, particularly with CD-19 targeted CAR-T cells, however, many participants are refractory or relapse after response. Responses are more limited in CLL/SLL, possibly secondary to the suppressive effect of circulating B cells on T cell function. BAFF receptor is a target that has been explored in CLL. Preclinical data indicates that CAR- T cells expressing B-cell activating factor (BAFF) can be another effective strategy to treat refractory CLL. This study aims to explore the efficacy of LMY-920 a BAFF-ligand CAR T cells with depletion of B cells with Obinutuzumab prior to apheresis.
This description comes directly from the study's public registry record.
Paolo Caimi, MD · 1-866-223-8100 · TaussigResearch@ccf.orgarch@ccf.org
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| Case Comprehensive Cancer Center, Cleveland Clinic Foundation Taussig Cancer Institute | Cleveland, Ohio, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06916767