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Study identifier: NCT06914609 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

REVEAL: A Phase 3 Study of ION582 in Angelman Syndrome

Condition: Angelman Syndrome  ·  Sponsor: Ionis Pharmaceuticals, Inc.

PhasePhase 3
Planned participants158
Who can joinAll sexes, 2 Years to 50 Years
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the efficacy and safety of ION582 in children and adults with Angelman syndrome caused by a deletion or mutation of the UBE3A gene.

This description comes directly from the study's public registry record.

Talk to the study team

Ionis Pharmaceuticals, Inc.  ·  (844) 285-7172  ·  IonisION582-CS2@clinicaltrialmedia.com

Always discuss trial participation with your own doctor first.

Locations (40)

Cedars-Sinai Medical CenterLos Angeles, California, United StatesRecruiting
Rady Children's HospitalSan Diego, California, United StatesRecruiting
Colorado Children's Hospital Research InstituteAurora, Colorado, United StatesRecruiting
Children's National HospitalWashington D.C., District of Columbia, United StatesRecruiting
Nicklaus Children's HospitalMiami, Florida, United StatesRecruiting
Children's Healthcare of AtlantaAtlanta, Georgia, United StatesRecruiting
Rush University Medical CenterChicago, Illinois, United StatesRecruiting
Boston Children's HospitalBoston, Massachusetts, United StatesRecruiting
Children's MercyKansas City, Missouri, United StatesRecruiting
Ichan School of Medicine at Mount SinaiNew York, New York, United StatesRecruiting
Columbia University Irving Medical CenterNew York, New York, United StatesRecruiting
University of North Carolina at Chapel Hill School of MedicineCarrboro, North Carolina, United StatesRecruiting

+ 28 more locations — full list on the registry record.

Follow this study

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Source record: clinicaltrials.gov/study/NCT06914609