Condition: Depressive Disorder, Major · Sponsor: Peking University Sixth Hospital
Major Depressive Disorder (MDD) is a chronic disease characterized by a high prevalence, low cure rate, and significant disability. Globally, depression is recognized as the leading cause of illness and disability among children and adolescents. Bright light therapy (BLT) has been established as an effective treatment for seasonal affective disorder and has demonstrated considerable efficacy in adult patients with MDD. However, its application in adolescent patients with MDD remains largely unexplored. The aim of this clinical trial is to evaluate the clinical efficacy, onset time, safety, and applicability of BLT in adolescents with MDD and to explore the potential neural mechanisms by which BLT enhances emotional and cognitive function in this population. This is a multicenter, randomized, controlled, double-blind study. It will involve adolescents aged 13 to 17 who are either untreated or have been stable on medication for at least one week. Adolescents with MDD will be randomly assigned to one of three groups: a high-intensity bright white light intervention group, a medium-intensity bright white light intervention group, and a placebo control group receiving dim red light. Each group will undergo four weeks of light exposure, six days per week, for 40 minutes daily between 6:30 and 10:00 AM. During the light exposure period, follow-up assessments will be conducted every weekend, and participants will be followed for two weeks after the completion of light exposure.The pr…
This description comes directly from the study's public registry record.
Xiaozhen Lv · +8601062723705 · lxz120300@163.com
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| Beijing Huilongguan Hospital | Beijing, Beijing Municipality, China | Recruiting |
| Peking University Sixth Hospital | Beijing, Beijing Municipality, China | Recruiting |
| Yan'an Third People's Hospital | Yanan, Shanxi, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06913309