Condition: Head and Neck Neoplasms · Carcinoma, Squamous Cell · Neoplasm Recurrence, Local · Sponsor: University of Chicago
This Phase I clinical trial evaluates the safety, tolerability, and optimal dosing of Zanzalintinib in combination with Pembrolizumab and Cetuximab in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M HNSCC). The study aims to establish the maximally tolerated dose (MTD) and recommended Phase II dose (RP2D) while also exploring efficacy outcomes, including progression-free survival (PFS) and overall survival (OS).
This description comes directly from the study's public registry record.
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| University of Chicago Medicine Comprehensive Cancer Center | Chicago, Illinois, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06912087