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Study identifier: NCT06911008 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

MTI-301 for the Treatment of Metastatic or Unresectable and Refractory Solid Cancers

Condition: Metastatic Malignant Solid Neoplasm · Refractory Malignant Solid Neoplasm · Unresectable Malignant Solid Neoplasm  ·  Sponsor: Mayo Clinic

PhasePhase 1
Planned participants42
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This phase I trial tests the safety, side effects, and best dose of MTI-301 in treating patients with solid cancers that have spread from where they first started (primary site) to other places in the body (metastatic) or that cannot be removed by surgery (unresectable) and that have not responded to previous treatment (refractory). MTI-301 is a drug that inhibits an enzyme called SCD1. SCD1 is an enzyme that promotes tumor growth and spread and is upregulated in some cancer types. MTI-301 may disrupt the activity of SCD1, which may lead to reduced tumor growth and/or spread.

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trials Referral Office  ·  855-776-0015  ·  mayocliniccancerstudies@mayo.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Mayo Clinic in FloridaJacksonville, Florida, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06911008