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Study identifier: NCT06910241 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Lidocaine Versus Diphenhydramine to Achieve Local Anesthesia for Laceration Repairs

Condition: Laceration of Skin  ·  Sponsor: Florida Atlantic University

PhasePhase 3
Planned participants100
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersYes

About this study

Diphenhydramine, when injected locally, has been shown to achieve a certain level of local anesthesia. It has been documented for use in simple bedside procedures, however there is a gap in knowledge in its comparison to lidocaine. The purpose of the study is to determine if local infiltration of diphenhydramine is noninferior to the use of lidocaine 1% when trying to achieve local anesthesia for simple laceration repair. Patients who present to the emergency department with a simple laceration will be enrolled in the study. Patients will be evaluated for the pain of the injection as well as the pain of the laceration repair procedure post injection.

This description comes directly from the study's public registry record.

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Contact details are listed per location below or on the registry record.

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Locations (1)

Bethesda Hospital EastBoynton Beach, Florida, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06910241