Condition: Pharmacogenomic Drug Interaction · Sponsor: NHS Greater Glasgow and Clyde
It is known that individuals respond differently to the same medicine with some people benefitting, some experiencing no effect and others suffering side-effects or even coming to harm. Some of the differences in response to medications can be explained by our genes. Genes are short sections of DNA. Each individual has over 20,000 different genes. Genes carry instructions for making the proteins needed to build things within the body including the sites where medicines act. Pharmacogenomics is the study of how our genes affect the way our body responds to medications. Doctors can test for gene variations that might put an individual at risk of severe side-effects or mean that they are likely to receive no benefit from a specific medicine. Though not widely available in the NHS, testing allows doctors and patients to chose a different dose or avoid the medicine completely. It is estimated that almost everyone in the population (\>95%) carries at least one gene variation that affects our response to medicines. The PHOENIX study will recruit 4,000 participants who are admitted to hospital or attend an outpatient clinic who require a new drug prescription. The new drug prescription will be one who known pharmacogenomic implications. A cheek (buccal) swab will be taken which can be used to test a large number of genes known to alter the response to medicines. Around half of the participants will be tested immediately whilst the other half will have the test after three months. T…
This description comes directly from the study's public registry record.
Elaine O'Neill · 0141 451 6869 · elaine.oneill3@nhs.scot
Stefanie Lip, PhD MBChB BSc · stefanie.lip@glasgow.ac.uk
Always discuss trial participation with your own doctor first.
| Golden Jubilee National Hospital | Clydebank, United Kingdom | Recruiting |
| Queen Elizabeth University Hospital | Glasgow, United Kingdom | Recruiting |
| Glasgow Royal Infirmary | Glasgow, United Kingdom | Recruiting |
| Leverndale Hospital | Glasgow, United Kingdom | Recruiting |
| Royal Alexandra Hospital | Glasgow, United Kingdom | Active Not Recruiting |
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Source record: clinicaltrials.gov/study/NCT06907784