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Study identifier: NCT06906211 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Low Intensity Focused Ultrasound for Chronic Pain: High Resolution Targeting of The Human Insula

Condition: Chronic Back Pain · Chronic Pain (Back / Neck)  ·  Sponsor: Washington D.C. Veterans Affairs Medical Center

PhaseNA
Planned participants66
Who can joinAll sexes, 21 Years to 75 Years
Healthy volunteersNo

About this study

In this study, the research team will use low-intensity focused ultrasound (LIFU) to temporarily change brain activity in a brain region that is known to be involved in chronic pain. Through this, the research team hopes to learn about how the brain area works in response to pain. There are main questions this study aims to answer: * The effect of LIFU to inhibit the posterior region of the insula (PI) compared to sham stimulation in individuals with chronic back pain (CBP) and widespread pain symptoms. * The effect of LIFU to PI compared to sham stimulation to reduce pain intensity and magnitude of the Neurologic Pain Signature (NPS) in response to evoked thermal pain. * The effect of LIFU to PI compared to sham stimulation to reduce pain intensity and magnitude of Tonic Pain Signature in response to tonic pain.

This description comes directly from the study's public registry record.

Talk to the study team

Mary R Lee, MD  ·  202-745-8000  ·  mary.lee3@va.gov

Evan Evan Lindeman, MS  ·  evan.lindeman@va.gov

Always discuss trial participation with your own doctor first.

Locations (1)

Washington DC Veterans Affairs Medical CenterWashington D.C., District of Columbia, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06906211