Condition: Nausea and Vomiting Chemotherapy-Induced · Nausea Post Chemotherapy · Sponsor: Helsinn Healthcare SA
Chemotherapy often causes nausea and vomiting (CINV), and this is a major problem for the children being treated for cancer. To prevent this, a combination of two substances in fixed proportion (IV NEPA) was developed. The two substances are: palonosetron, an antagonist of 5 HT3 receptors, and fosnetupitant, an antagonist of NK1 receptors that transforms into netupitant in the body. The medication is administered through intravenous injection (IV- drip). This study is built from 2 parts: Part 1: phase 2, open label Part 2: phase 3 double blind The detailed description, study design, study milestones and eligibility criteria will reflect the Part 1 requirements
This description comes directly from the study's public registry record.
Tulla Spinelli Head of Clinical Affairs, PharmD, PhD · +41919852121 · tulla.spinelli@helsinn.com
Always discuss trial participation with your own doctor first.
| Aghia Sophia Children's Hospital, Pediatric Hematology/ Oncology Unit (POHemU) | Athens, Greece | Recruiting |
| "AHEPA" University General Hospital of Thessaloniki, 2nd Department of Pediatrics | Thessaloniki, Greece | Recruiting |
| Department of Pediatrics, Oncology and Hematology University Children's Clinical Hospital them. Ludwik Zamenhof in Bialystok | Bialystok, Poland | Withdrawn |
| Department of Paediatrics, Haematology, Oncology and Rheumatology Voivodship Children's Hospital them. J. Brudziński | Bydgoszcz, Poland | Recruiting |
| Clinic of Pediatrics, Oncology and Hematology University Pediatric Center them M. Konopnicka SP ZOZ Central Clinical Hospital Medical University of Lodz | Lodz, Poland | Recruiting |
| University Children'S Hospital in Lublin, Department of Pediatric Hematology, Oncology, and Transplantology | Lublin, Poland | Not Yet Recruiting |
| Clinical Department of Paediatric Oncology and Haematology VOIVODSHIP SPECIALIST CHILDREN'S HOSPITAL them. prof. dr. Stanisław Popowski in Olsztyn | Olsztyn, Poland | Withdrawn |
| Department of Pediatric Oncology, Hematology and Transplantation Clinical Hospital them. Karol Jonscher Medical University them. Karol Marcinkowski in Poznań | Poznan, Poland | Recruiting |
| Department of Paediatrics and Paediatric Haemato-Oncology University Clinical Hospital No. 1 them. prof. Tadeusz Sokołowski Pomeranian Medical University | Szczecin, Poland | Withdrawn |
| Department of Paediatrics, Oncology and Paediatric Immunology, University Clinical Hospital No. 1 them. prof. Tadeusz Sokołowski Pomeranian Medical University in Szczecin | Szczecin, Poland | Recruiting |
| Department of Oncology and Surgical Oncology for Children and Youth Institute Mother and Child | Warsaw, Poland | Recruiting |
| Department of Oncology Institute "Monument - Child Health Center" | Warsaw, Poland | Recruiting |
+ 8 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06904235