Condition: Colorectal Cancer · Microsatellite Instability High · Mismatch Repair Deficiency · Sponsor: Sun Yat-sen University
The PICC-3 study is a multicentre, single-arm, phase II trial evaluating toripalimab plus celecoxib in patients with mismatch repair-deficient (dMMR) or microsatellite instability-high (MSI-H) locally advanced colorectal cancer. The trial uses a response-adapted treatment strategy, whereby patients with clinical complete response (cCR) after therapy may enter a non-operative management pathway, while patients without cCR proceed to surgery. Response assessment is based on imaging, endoscopy, biopsy evaluation, and ctDNA analysis.
This description comes directly from the study's public registry record.
Yanhong Deng, MD. · 020-38379762 · dengyanh@mail.sysu.edu.cn
Always discuss trial participation with your own doctor first.
| The Sixth Affiliated Hospital, Sun Yat-sen University | Guangzhou, Guangdong, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06903858