Condition: Autosomal Dominant Polycystic Kidney Disease · Sponsor: Calico Life Sciences LLC
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common genetic cause of kidney disease that causes fluid-filled cysts to develop in the kidneys. The purpose of this study is to assess the safety and efficacy of ABBV-CLS-628 for the treatment of ADPKD in adult participants. ABBV-CLS-628 is an investigational drug being developed for the treatment of ADPKD. Participants are placed in 1 of 4 groups, called treatment arms. Each group receives a different treatment. There is a 1 in 4 chance that participants will be assigned to placebo. Around 240 adult participants with ADPKD will be enrolled at approximately 100 sites worldwide. Participants will receive IntraVenous ABBV-CLS-628 or placebo every 4 weeks for 92 weeks. Participants will be followed for up to 15 weeks. There may be higher treatment burden for participants in this trial compared to their standard of care . Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
This description comes directly from the study's public registry record.
Calico Clinical Trial Communication · 650-754-6200 · clinicaltrialcommunication@calicolabs.com
Always discuss trial participation with your own doctor first.
| National Institute of Clinical Research - Garden Grove /ID# 271418 | Garden Grove, California, United States | Recruiting |
| Valiance Clinical Research - Huntington Park /ID# 270634 | Huntington Park, California, United States | Recruiting |
| Academic Medical Research Institute - Los Angeles /ID# 270502 | Los Angeles, California, United States | Recruiting |
| UC Irvine Medical Center /ID# 270811 | Orange, California, United States | Recruiting |
| University Of California, San Francisco /ID# 270326 | San Francisco, California, United States | Recruiting |
| Yale University School of Medicine /ID# 270675 | New Haven, Connecticut, United States | Recruiting |
| Horizon Research Group - Coral Gables /ID# 270857 | Coral Gables, Florida, United States | Recruiting |
| South Florida Research Institute /ID# 270848 | Fort Lauderdale, Florida, United States | Recruiting |
| Nature Coast Clinical Research - Inverness /ID# 270875 | Inverness, Florida, United States | Recruiting |
| Mayo Clinic Hospital Jacksonville /ID# 271011 | Jacksonville, Florida, United States | Recruiting |
| Panax Clinical Research /ID# 270851 | Miami, Florida, United States | Recruiting |
| Infigo Clinical Research /ID# 270844 | Sanford, Florida, United States | Recruiting |
+ 63 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06902558