Condition: Locally Advanced Adrenal Cortical Carcinoma · Metastatic Adrenal Cortical Carcinoma · Recurrent Adrenal Cortical Carcinoma · Sponsor: National Cancer Institute (NCI)
This phase II trial compares the effect of giving cabozantinib with or without cemiplimab in patients with adrenocortical cancer that has spread to nearby tissue or lymph nodes (locally advanced), and that cannot be removed by surgery (unresectable) or that has come back after a period of improvement (recurrent) or that has spread from where it first started (primary site) to other places in the body (metastatic). Cabozantinib is in a class of medications called tyrosine kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply, which may help keep cancer cells from growing. Immunotherapy with monoclonal antibodies, such as cemiplimab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving cabozantinib with cemiplimab may kill more tumor cells in patients with locally advanced unresectable or recurrent/metastatic adrenocortical cancer.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| UC San Diego Moores Cancer Center | La Jolla, California, United States | Recruiting |
| Valley Children's Hospital | Madera, California, United States | Recruiting |
| UCHealth University of Colorado Hospital | Aurora, Colorado, United States | Recruiting |
| Lurie Children's Hospital-Chicago | Chicago, Illinois, United States | Recruiting |
| Northwestern University | Chicago, Illinois, United States | Recruiting |
| Carle at The Riverfront | Danville, Illinois, United States | Recruiting |
| Northwestern Medicine Cancer Center Kishwaukee | DeKalb, Illinois, United States | Recruiting |
| Carle Physician Group-Effingham | Effingham, Illinois, United States | Recruiting |
| Northwestern Medicine Cancer Center Delnor | Geneva, Illinois, United States | Recruiting |
| Northwestern Medicine Glenview Outpatient Center | Glenview, Illinois, United States | Recruiting |
| Northwestern Medicine Grayslake Outpatient Center | Grayslake, Illinois, United States | Recruiting |
| Northwestern Medicine Lake Forest Hospital | Lake Forest, Illinois, United States | Recruiting |
+ 65 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06900595