Condition: Bronchiectasis Adult · Sponsor: Shanghai Pulmonary Hospital, Shanghai, China
Bronchiectasis is a heterogeneous airway disease with diverse causes, making precise diagnosis, prognosis, and treatment response prediction challenging. Identifying patient subgroups (phenotypes) and molecular profiles (endotypes) can enhance individualized assessment and management. While prior studies, primarily in European populations, have identified key phenotypes and endotypes, their relevance to Chinese patients remains unclear due to geographic and clinical differences. Specific causes of bronchiectasis, such as allergic bronchopulmonary aspergillosis (ABPA) and primary ciliary dyskinesia (PCD), may also exhibit distinct pathophysiology requiring further exploration. The C-BRIDGE Study seeks to characterize phenotypes and endotypes in Chinese bronchiectasis patients during stable disease and exacerbations, evaluate differences in clinical outcomes across these subgroups, and develop personalized medicine strategies based on these findings, applicable in China and globally. Primary Objective: To identify molecular endotypes of bronchiectasis that accurately predict prognosis and guide treatment responses. Secondary Objectives: To characterize molecular endotypes of stable bronchiectasis in Chinese patients. To define molecular endotypes of bronchiectasis exacerbations in Chinese patients. To investigate molecular endotypes specific to allergic bronchopulmonary aspergillosis (ABPA). To explore genotypes and inflammatory endotypes of cystic fibrosis (CF) and prima…
This description comes directly from the study's public registry record.
Yong-hua Gao, Ph.D. · +86 17321278520 · gaoyonghuahust@163.com
Always discuss trial participation with your own doctor first.
| Lin Liu | Guiyang, Guizhou, China | Recruiting |
| Lei Song | Changchun, Jilin, China | Recruiting |
| Qian Qi | Jinan, Shangdong, China | Recruiting |
| He-feng Chen | Shanghai, Shanghai Municipality, China | Recruiting |
| Zhou-fang Mei | Shanghai, Shanghai Municipality, China | Recruiting |
| Jun She | Shanghai, Shanghai Municipality, China | Recruiting |
| Xue-ling Wu | Shanghai, Shanghai Municipality, China | Recruiting |
| Yong-hua Gao | Shanghai, Shanghai Municipality, China | Recruiting |
| Xiao-long Ma | Jiaxing, Zhejiang, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06900062