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Study identifier: NCT06898450 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study to Assess the Safety, Tolerability, and Efficacy of NDI-219216 in Patients With Advanced Solid Tumors.

Condition: Advanced Solid Tumors Cancer · MSI-H Cancer  ·  Sponsor: Nimbus Wadjet, Inc.

PhasePhase 1/Phase 2
Planned participants134
Who can joinAll sexes, 18 Years to 99 Years
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn if NDI-219216 is safe for patients, and if NDI-219216 might be a possible treatment for advanced solid tumors in the later phases of the study. The main questions it aims to answer are: Is NDI-219216 safe and what kinds of side effects might it cause? What kind of effects does NDI-219216 have on the body? Does NDI-219216 have any impact on tumor size? Participants will: Take NDI-219216 every day by mouth. Visit the clinic 6 times during Cycle 1, 2 times during Cycle 2, once a month thereafter for checkups and tests while on the study, then one time for an end of treatment visit. After the End of Study, a follow up will occur but can be done on the phone. Keep a diary of their tablet consumption and symptoms experienced.

This description comes directly from the study's public registry record.

Talk to the study team

Sean Rossi  ·  857-600-8779  ·  sean.rossi@nimbustx.com

Katie Ard, MSN  ·  303-646-7297  ·  katie.ard@nimbustx.com

Always discuss trial participation with your own doctor first.

Locations (22)

USC Norris Comprehensive Cancer CenterLos Angeles, California, United StatesRecruiting
University of Chicago MedicineChicago, Illinois, United StatesRecruiting
University of Louisville James Graham Brown Cancer CenterLouisville, Kentucky, United StatesRecruiting
Cayuga Cancer CenterIthaca, New York, United StatesTerminated
Levine Cancer CenterCharlotte, North Carolina, United StatesRecruiting
Atrium Health Wake Forest Baptist CenterWinston-Salem, North Carolina, United StatesRecruiting
Taylor Cancer Research CenterMaumee, Ohio, United StatesRecruiting
Brown University HealthProvidence, Rhode Island, United StatesRecruiting
Prisma Health Cancer Institute - Multidisciplinary CenterGreenville, South Carolina, United StatesRecruiting
University of Virginia Emily Couric Clinical Cancer CenterCharlottesville, Virginia, United StatesRecruiting
Virginia Cancer Specialists, P.C. - FairfaxFairfax, Virginia, United StatesRecruiting
Liverpool HospitalLiverpool, New South Wales, AustraliaRecruiting

+ 10 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06898450