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Study identifier: NCT06897644 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Gemcitabine Plus Nab-paclitaxel as Switch Maintenance Versus Continuation of Modified FOLFIRINOX as 1st Line Chemotherapy in Patients With Advanced Pancreatic Cancer.

Condition: Pancreatic Adenocarcinoma Advanced or Metastatic  ·  Sponsor: Gruppo Oncologico del Nord-Ovest

PhasePhase 3
Planned participants340
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

PANThEON is a randomized, open-label, multicenter phase III trial aimed at comparing the switch maintenance with gemcitabine plus nab-paclitaxel (ARM B) versus mFOLFIRINOX continuation (ARM A) in terms of overall survival (OS) in patients with unresectable LAD or mPDAC without disease progression following 3 months of induction mFOLFIRINOX triplet chemotherapy.

This description comes directly from the study's public registry record.

Talk to the study team

Monica Niger, MD  ·  +3902 2390 2919  ·  monica.niger@istitutotumori.mi.it

Always discuss trial participation with your own doctor first.

Locations (28)

Centro Di Riferimento Oncologico Di AvianoAviano, Italy, ItalyRecruiting
University Hospital Consorziale PoliclinicoBari, Italy, ItalyNot Yet Recruiting
Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di BresciaBrescia, Italy, ItalyNot Yet Recruiting
ASST Ospedale Maggiore di CremaCrema, Italy, ItalyRecruiting
Azienda Socio Sanitaria Territoriale Di CremonaCremona, Italy, ItalyNot Yet Recruiting
Careggi University HospitalFlorence, Italy, ItalyNot Yet Recruiting
IRCCS Ospedale Policlinico San MartinoGenoa, Italy, ItalyNot Yet Recruiting
Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST S.r.l.Meldola, Italy, ItalyRecruiting
Fondazione IRCCS Ca Granda Ospedale Maggiore PoliclinicoMilan, Italy, ItalyNot Yet Recruiting
Fondazione IRCCS Istituto Nazionale dei TumoriMilan, Italy, ItalyNot Yet Recruiting
Istituto Europeo Di Oncologia S.r.l.Milan, Italy, ItalyNot Yet Recruiting
ASST Grande Ospedale Metropolitano NiguardaMilan, Italy, ItalyRecruiting

+ 16 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06897644