Condition: Polycystic Ovary Syndrome (PCOS) Women · Obesity · Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder that is frequently associated with metabolic features, including obesity. Improvement of metabolic manifestations helps in the control of symptoms, including subfertility. Metformin has been commonly used to decrease insulin resistance and weight in PCOS patients suffering from obesity. Glucagon-like peptide (GLP-1) agonist semaglutide is also effective in managing different metabolic features, including obesity and insulin resistance. There is limited data about using a combination of semaglutide and metformin in women with PCOS suffering from obesity. This study aims to compare the metabolic changes after giving a combination of low-dose semaglutide and metformin vs. metformin alone over 12 weeks among women with PCOS and obesity. This open label randomized trial will be conducted in the Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU). After obtaining informed written consent, a total of 30 patients with PCOS and obesity will be enrolled conveniently (sampling) in the study as per inclusion and exclusion criteria from the outdoor, indoor, and PCOS clinic, Endocrinology, BSMMU. Study participants will be divided into two groups randomly by a computerized random number generator (allocation). One study arm will be treated with low-dose subcutaneous semaglutide (0.25 mg/week for 4 weeks followed by 0.5mg per week for 12 weeks) in combination with metformin (500 mg bid). Another stu…
This description comes directly from the study's public registry record.
Muhammad Abul Hasanat, MD · +880 1711-670735 · hasnat_endo@bsmmu.edu.bd
Hurjahan Banu, FCPS · +880 1712-614949 · dr.hurjahan_banu@yahoo.com
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| Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University | Dhaka, Dhaka Division, Bangladesh | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06896981