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Study identifier: NCT06894004 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Mechanism of Ketogenic Diet-Induced Hypercholesterolemia

Condition: Hypercholesterolemia and Hyperlipidemia  ·  Sponsor: Washington University School of Medicine

PhaseNA
Planned participants100
Who can joinAll sexes, 18 Years to 39 Years
Healthy volunteersYes

About this study

Very-low carbohydrate ketogenic diets can dramatically increase blood cholesterol levels, particularly in normal-weight people, for reasons that are not well understood. This study will enroll normal-weight adults, will identify "responders" who develop high cholesterol on a ketogenic diet, and will measure rates of production and removal of certain types of cholesterol-carrying particles called lipoproteins in responders. The results will clarify the mechanism by which a ketogenic diet can cause high cholesterol in certain susceptible people.

This description comes directly from the study's public registry record.

Talk to the study team

Frannie Wilkinson, M.A.  ·  (314) 362-0590  ·  francesw@wustl.edu

Max C Petersen, M.D., Ph.D.  ·  314-362-8352  ·  max.p@wustl.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Washington University School of MedicineSt Louis, Missouri, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06894004