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Study identifier: NCT06892704 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Olfactory Cleft Obstruction and Electrophysiological Field Potentials Predict Olfactory Restoration by Dupilumab in CRSwNP Patients.

Condition: Chronic Rhinosinusitis Phenotype With Nasal Polyps (CRSwNP) · Smell Loss  ·  Sponsor: Northwestern University

PhaseN/A
Planned participants30
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

The goal of this observational study is to learn what can predict the return of the sense of smell in patients with chronic rhinosinusitis with nasal polyps being treated with dupilumab. The main questions it aims to answer are: 1. Does obstruction of the olfactory cleft predict return of the sense of smell? 2. Do electrophysiological signals generated by breathing and sniffing behavior predict return of the sense of smell? Participants starting dupilumab will undergo assessment for their degree of olfactory cleft obstruction, and an electrophysiologic assessment of their olfactory cleft and be followed over 6 months of treatment with dupilumab.

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Coordinator  ·  312 6958182  ·  aditi.agarwal@northwestern.edu

Bruce Tan, MD  ·  312 6958182  ·  btan@nm.org

Always discuss trial participation with your own doctor first.

Locations (1)

Northwestern University Feinberg School of MedicineChicago, Illinois, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06892704