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Study identifier: NCT06892548 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer

Condition: Advanced Lung Cancer  ·  Sponsor: BioNTech SE

PhasePhase 1/Phase 2
Planned participants594
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study aims to investigate the combination of BNT324, a B7-H3 antibody-drug conjugate (ADC) with BNT327, a programmed death-ligand 1 (PD-L1) and vascular endothelial growth factor (VEGF) bispecific antibody, in participants with advanced/metastatic or relapsed/progressive small cell lung cancer (SCLC) and non small cell lung cancer (NSCLC).

This description comes directly from the study's public registry record.

Talk to the study team

BioNTech clinical trials patient information  ·  +49 6131 9084  ·  patients@biontech.de

Always discuss trial participation with your own doctor first.

Locations (88)

Mayo Clinic ArizonaPhoenix, Arizona, United StatesRecruiting
Precision NextGen Oncology and Research CenterBeverly Hills, California, United StatesRecruiting
Cedars Sinai Medical CenterLos Angeles, California, United StatesRecruiting
UCLA - David Geffen School of MedicineSanta Monica, California, United StatesRecruiting
University of Colorado Cancer CenterAurora, Colorado, United StatesRecruiting
Mayo Clinic in FloridaJacksonville, Florida, United StatesRecruiting
University of Iowa Hospitals & Clinics PARENTIowa City, Iowa, United StatesRecruiting
Mayo Clinic-RochesterRochester, Minnesota, United StatesRecruiting
John Theurer Cancer Center at Hackensack UMCHackensack, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Cancer Center (MSKCC)New York, New York, United StatesRecruiting
Icahn School of Medicine at Mount Sinai PRIMENew York, New York, United StatesRecruiting
Cleveland Clinic Taussig Cancer Institute Case Comprehensive Cancer CenterCleveland, Ohio, United StatesRecruiting

+ 76 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06892548