Condition: Acute Myeloid Leukaemia · MDS (Myelodysplastic Syndrome) · MPN (Myeloproliferative Neoplasms) · Sponsor: Istituto Clinico Humanitas
The goal of this clinical trial is to evaluate the effectiveness and safety of the anti-NKG2A monoclonal antibody (Monalizumab) in patients undergoing haploidentical stem cell transplantation (Haplo-SCT) with post-transplantation cyclophosphamide (PT-Cy). The main questions this trial aims to answer are: * Does Monalizumab improve graft-versus-host disease-free and progression-free survival (GPFS) in patients after Haplo-SCT? * What are the safety and side effects of Monalizumab in this patient group? * How does Monalizumab affect the reconstitution and function of NK cells in patients undergoing Haplo-SCT? * Researchers will administer Monalizumab to participants on day +30 and +44 after transplantation to see if it enhances immune responses and prevents disease relapse or GVHD. Participants will: * Receive Monalizumab intravenously at 1 mg/kg on day +30 and day +44 after Haplo-SCT * Be monitored for clinical outcomes such as GVHD, survival rates, and immune function for up to one year after the transplant * Undergo regular checkups and tests to assess the effectiveness and safety of the treatment
This description comes directly from the study's public registry record.
DOMENICO MAVILIO, MD · +39 02 8224 5157 · domenico.mavilio@humanitas.it
Always discuss trial participation with your own doctor first.
| IRCCS Ospedale Policlinico San Martino | Genova, GENOVA, Italy | Recruiting |
| Irccs Istituto Clinico Humanitas | Rozzano, MILANO, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06892223