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Study identifier: NCT06891287 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

An Early Phase Study of RT-114 (RaniPill Containing PG-102, a GLP-1/2 Dual Agonist) in Healthy Volunteers.

Condition: Obesity  ·  Sponsor: RANI Therapeutics

PhasePhase 1
Planned participants60
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersYes

About this study

The goal of this Phase 1 study is to evaluate the safety and tolerability of RT-114 in healthy volunteers. The main objectives are: Primary: To evaluate safety and tolerability of RT-114 when administered as single and multiple doses by assessing treatment emergent adverse events (TEAEs) in healthy volunteers Secondary: * To determine the pharmacokinetics of RT-114 administered as single and multiple doses * To determine the pharmacodynamic effects of RT-114 administered as multiple doses In the single dose portion of the study participants will either receive the drug via a subcutaneous injection or an oral pill (RT-114). In the repeat dose portion of the study participants will randomized to either RT-114 or a placebo.

This description comes directly from the study's public registry record.

Talk to the study team

Arvinder Dhalla, PhD  ·  (408) 457-3700  ·  arvinder@ranitherapeutics.com

Always discuss trial participation with your own doctor first.

Locations (1)

Nucleus NetworkMelbourne, Victoria, AustraliaRecruiting

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Source record: clinicaltrials.gov/study/NCT06891287