Condition: Crohn Disease · Sponsor: All India Institute of Medical Sciences
Dysbiosis can be rectified by several methods: antibiotics, prebiotics, probiotics, dietary modulation, and fecal microbiota transplantation. There has been limited success with the isolated use of antibiotics and pre/probiotics in the treatment of IBD. Among the measures of dietary manipulation, the use of exclusive enteral nutrition (EEN) has shown superior, or at least equivalent, efficacy compared with steroids in pediatric CD. Although the results in adults are not as encouraging, recent cohort studies in patients with complicated CD have shown good success rates. Definite exclusion diets that exclude pro-inflammatory dietary constituents have also been tested with good clinical efficacy in patients with CD, who even failed treatment with anti-TNF agents. Various dietary approaches, inclusive of exclusive enteral nutrition, partial enteral nutrition, and Crohn's disease exclusion diet have been reported to be of benefit and are associated with changes in gut microbiome. Fecal microbiota transplantation (FMT) defined as the infusion of fecal suspension from a healthy individual into the gastrointestinal tract of an individual with GI disease carries a diverse population of microbiota and their metabolites and has been tested with varying efficacy in IBD. In general, FMT has shown good success rates in randomized control trials in patients with UC who failed conventional agents. Although limited small RCTs exist in CD, cohort studies have also shown good success rates. The…
This description comes directly from the study's public registry record.
Prof Vineet Ahuja, DM Gastroenterology · +91-9810707170 · vineet.aiims@gmail.com
Dr Himanshu Narang, DM Gasteroentrology · +91-8800316504 · h92narang@gmail.com
Always discuss trial participation with your own doctor first.
| Department of Gastroenterology, Lisie Hospital | Kochi, Kerala, India | Not Yet Recruiting |
| Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College, Sion | Mumbai, Maharashtra, India | Not Yet Recruiting |
| Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences | New Delhi, National Capital Territory of Delhi, India | Recruiting |
| Department of Gastroenterology, Dayanand Medical College | Ludhiana, Punjab, India | Not Yet Recruiting |
| Department of Gastroentrology, Postgraduate Institute of Medical Education and Research | Chandigarh, Punjab/Haryana, India | Not Yet Recruiting |
| Department of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University | Varanasi, Uttar Pradesh, India | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06890650