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Study identifier: NCT06890598 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

Condition: Carcinoma, Non-Small-Cell Lung  ·  Sponsor: Eli Lilly and Company

PhasePhase 3
Planned participants700
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The main purpose of this study is to assess if olomorasib in combination with pembrolizumab is more effective than the pembrolizumab and placebo combination in part A in participants with resected KRAS G12C-mutant NSCLC and to assess if olomorasib in combination with durvalumab is more effective than the durvalumab and placebo combination in part B in participants with unresectable KRAS G12C-mutant non-small cell lung cancer. The study may last up to 3 years for each participant.

This description comes directly from the study's public registry record.

Talk to the study team

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or  ·  1-317-615-4559  ·  LillyTrials@Lilly.com

Physicians interested in becoming principal investigators please contact  ·  clinical_inquiry_hub@lilly.com

Always discuss trial participation with your own doctor first.

Locations (366)

Clearview Cancer InstituteHuntsville, Alabama, United StatesRecruiting
Infirmary Cancer CareMobile, Alabama, United StatesSuspended
City of Hope, PhoenixPhoenix, Arizona, United StatesNot Yet Recruiting
The University of Arizona Cancer Center - North CampusTucson, Arizona, United StatesRecruiting
Highlands Oncology GroupSpringdale, Arkansas, United StatesRecruiting
UCLA Hematology/Oncology - Santa MonicaLos Angeles, California, United StatesNot Yet Recruiting
Profound Research LLCOceanside, California, United StatesRecruiting
University of California, Irvine (UCI) Health - UC Irvine Medical CenterOrange, California, United StatesNot Yet Recruiting
Stanford Cancer CenterPalo Alto, California, United StatesRecruiting
Kaiser Permanente San Diego Mission RoadSan Diego, California, United StatesRecruiting
BASS Cancer CenterWalnut Creek, California, United StatesRecruiting
Hartford Hospital (HH)Hartford, Connecticut, United StatesRecruiting

+ 354 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06890598