Condition: Atrial Fibrillation (AF) · Catheter Ablation · Atrial Functional Mitral Regurgitation · Sponsor: Beijing Anzhen Hospital
Atrial fibrillation (AF) leads to atrial functional mitral regurgitation (MR) through mechanisms including mitral annular dilatation, systolic leaflet motion distance alteration, and contractility decrease. Compared with primary MR, atrial functional MR due to AF and other diseases tends to have a worse prognosis, with a higher risk of death and heart failure hospitalization. MR and AF co-exist and exacerbate left atrial dysfunction, further causing worse cardiac dysfunction, valvular regurgitation, and aggravating prognosis. The best therapy for secondary MR is unclear because MR is only one component of the disease, and restoration of mitral valve competence is not curative. Catheter ablation improves symptoms and cardiac function in patients with AF, reduces risks of AF recurrence and hospitalization, as well as increases quality of life. For patients with AF combined with functional moderate-to-severe MR, previous observational studies have found that the severity of MR significantly reduced after taking catheter ablation to restore sinus rhythm. We hypothesized that catheter ablation would significantly improve the severity of MR in patients with severe atrial functional MR combined with persistent AF compared with drug therapy alone.
This description comes directly from the study's public registry record.
liu HE, MD · +86 13810720787 · theliu@139.com
Caihua Sang, MD
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| The First Affiliated Hospital of Anhui Medical University | Hefei, Anhui, China | Recruiting |
| Beijing Anzhen Hospital, Capital Medical University | Beijing, Beijing Municipality, China | Recruiting |
| Peking University Third Hospital | Beijing, Beijing Municipality, China | Recruiting |
| Xiamen University Affiliated Cardiovascular Hospital | Xiamen, Fujian, China | Not Yet Recruiting |
| Guangdong Provincial People's Hospital | Guangzhou, Guangdong, China | Not Yet Recruiting |
| The Second Hospital of Hebeimedical University | Shijiazhuang, Hebei, China | Recruiting |
| The First Affiliated Hospital of Harbin Medical University | Harbin, Heilongjiang, China | Recruiting |
| The Second Affiliated Hospital of Harbin Medical University | Harbin, Heilongjiang, China | Recruiting |
| The First Affiliated Hospital of Zhengzhou University | Zhengzhou, Henan, China | Not Yet Recruiting |
| Wuhan Asia Heart Hospital | Wuhan, Hubei, China | Recruiting |
| Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology | Wuhan, Hubei, China | Recruiting |
| The first hospital of Jilin University | Changchun, Jilin, China | Not Yet Recruiting |
+ 5 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06883864